Nature, Published online: 26 February 2026; doi:10.1038/d41586-026-00555-3
The 80386 introduced Virtual 8086 (V86) mode -- allowing real-mode DOS programs to run inside protected mode under OS supervision. While not full virtualization in the modern sense, V86 was the first practical hardware-assisted mechanism on x86 for running legacy software in a protected environment -- used widely in Windows 3.x and Windows 9x.
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